Molecular imaging is a new biomedical research discipline enabling the visualization, characterization, and quantification of biologic processes taking place at the cellular and subcellular levels within intact living subjects (according to the Molecular Imaging Center of Excellence). The term molecular imaging itself encompasses a new imaging paradigm that includes multiple image-capture techniques, cell and molecular biology, chemistry, pharmacology, medical physics, biomathematics, and bioinformatics.
Preclinical imaging (PCI) deals with the visualization, characterization, and quantification of biologic processes of living animals for research purposes. It is a well-established discipline that merges the tools of molecular and cell biology with state-of-the-art imaging technologies. Imaging modalities have long been crucial to the researcher in order to observe changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques. Techniques such as high-frequency micro-ultrasound (US), magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging (fluorescence and bioluminescence), fluorescence emission computed tomography (FLECT), photoacoustic tomography (PAT), positron emission tomography (PET), and single photon emission computed tomography (SPECT) are usually used for molecular visualizations.
As a company that aspires to design, develop and produce high-performance in vivo imaging technologies, TriFoil Imaging understands its role as an enabler of fundamental biological research, of cutting-edge discoveries in molecular diagnosis and therapy, and of drug development. Our instruments provide the tools for visualization and quantification of biological and biochemical processes in vivo at volume and concentration levels impossible just a few years ago. There is substantial development and effort required to transform our technical innovations from prototypes into products that enable high-level research. We are grateful to our users for providing the extensive input and feedback required to identify new technologies and applications, to overcome technical barriers and to refine our products into powerful, yet easy-to-use, life sciences research tools.
In the following pages, you will find examples of research investigations in areas such as oncology, neurobiology, cardiovascular and pulmonary research, regenerative medicine, inflammation, nephrology and toxicology.